Which piece of personal protective equipment is most appropriate when body fluids may spatter onto clothing?

The most appropriate piece of personal protective equipment when body fluids may spatter onto clothing is a gown. Gowns are specifically designed to protect the skin and clothing from contamination by providing a barrier against fluids. They are typically made from materials that are resistant to penetration by liquids, ensuring that any potential exposure from blood or other body fluids is contained and does not reach the clothing underneath.

While masks are essential for protecting the face and respiratory system from droplets and aerosols, they do not shield the body or clothing. Hairnets primarily serve to keep hair contained and prevent it from coming into contact with any materials but do not protect against body fluid exposure. Shoe covers are useful for protecting footwear but are less relevant in scenarios where body fluid spatter is a concern. Therefore, the gown is the best choice for safeguarding against potential contamination from bodily fluids.